PhD fellowship in Neuronal Cell and Membrane Biology at Neuropharmacology and Genetics, Department of Neuroscience

University of Copenhagen

Denmark

PhD fellowship in Neuronal Cell and Membrane Biology at Neuropharmacology and Genetics, Department of Neuroscience

Faculty of Health and Medical Sciences 

University of Copenhagen 

 

We are offering a PhD fellowship in Neuronal Cell and Membrane Biology commencing 1 April 2019 or as soon as possible hereafter. 

 

Our group and research 

Our research addresses fundamental aspects of basic pharmacology, molecular pharmacology and neuropharmacology, with certain translational parts. The work is divided into three Work Packages each containing a number of specific projects. Work Package 1 is focused on the pharmacology of PSD95/Disc-large/ZO-1 homology (PDZ) mediated proteins-protein interaction and how these domains might represent new attractive pharmacological targets as alternatives to surface receptors. Work Package 2 will seek to explore the controversial idea that trafficking of receptors and transporters, which in many cases is strongly integrated with their pharmacology, is determined not only by protein-protein interactions, but also by yet unappreciated protein-lipid interactions that govern localization of the receptors and transporters to areas of high membrane curvature in the plasma membrane. Work Package 3 is aimed at obtaining fundamental new understanding of dopamine signalling processes in the brain. Evidently, this has broad pharmacotherapeutic perspectives given the key role of dysfunctional dopamine signalling in many brain disease including schizophrenia, bipolar disorder, ADHD, Parkinsons’ Disease and drug abuse. 

 

Methodologically, we specialize in molecular biology, protein purification, receptor binding, advanced light microscopy, including live microscopy and fluorescence energy transfer microscopy (FRET), as well trafficking assays of integral membrane proteins using ELISA and confocal microscopy. 

 

Project description 

The PhD project fall within WP2 and is aimed at defining the role of amphipathic helices in transmebrane proteins for driving their internalization and endosomal sorting. Specifically, we will focus on the role of helix 8 in G-protein coupled receptors for driving constitutive internalization as well as newly identified AHs in neurotransmitter transporter for driving sorting during biogenesis. The project will involve cell biological work in cell lines and dissociated neuronal cultures as well as in vitro work with purified proteins, peptides and liposomes. Finally, in silico structural prediction and big data analysis will be employed. Methodologies will include flow cytometry, live fluorescence microscopy, super resolution microscopy, electron microscopy, liposome binding assays.  

 

Principal supervisor is Associate professor, Kenneth Lindegaard Madsen, Department of Neuroscience, kennethma@sund.ku.dk, Direct Phone: +45 23649401.

 

Job description 

Your key tasks as a PhD student at SUND are: 

  • Carry through an independent research project under supervision 

  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points 

  • Participate in active research environments including a stay at another research team 

  • Obtain experience with teaching or other types of dissemination related to your PhD project 

  • Teach and disseminate your knowledge 

  • Write a PhD thesis on the grounds of your project 

Key criteria for the assessment of applicants 

Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project e.g. Molecular Biomedicine, human Biology, Biochemistry etc. 

 

Other important criteria are: 

  • Experience in flow cytometry 

  • Experience in confocal microscopy  

  • Training in super-resolution microscopy  

  • Experience in molecular biology 

  • Experience in immunocytochemistry 

  • Experience in quantitative image analysis and scripting 

  • Curious mind-set with a strong interest in Protein Trafficking and Neuroscience 

  • Fluency in English 

Place of employment 

The place of employment is at Neuropharmacology and Genetics Lab, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories and access to all relevant experimental facilities. 

 

Terms of employment  

The employment as PhD fellow is full time and for 3 years.  

It is conditioned upon the applicant’s success­ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant. 

 

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 26.886 DKK /approx. 3.567 EUR (April 2018-level) plus pension. The position is covered by the Job Structure for Academic Staff at Universities (2013). 

 

Questions 

For specific information about the PhD fellowship, please contact the principal supervisor. 

General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/ 

 

Application procedure 

Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format:   

 

1. Motivated letter of application (max. one page)  

2. CV incl. education, experience, language skills and other skills relevant for the position  

3. Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do  

4. Publication list (if possible) 

 

Application deadline: 3 March 2019 

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements. 

 

The further process  

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.  

 

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement. 

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.  

 

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/  

 

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.  

 

Interviews are expected to be held in week 11 

 

The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.  


In your application, please refer to Professorpositions.com

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