PhD Fellowships in Transcription and the DNA Damage Response

University of Copenhagen Department of Cellular and Molecular Medicine

Denmark

PhD fellowships in Transcription and the DNA damage response in the Svejstrup laboratory at Department of Cellular and Molecular Medicine

Faculty of Health and Medical Sciences
University of Copenhagen

We are offering one or more PhD fellowships for talented and highly motivated students interested in investigating the interface between gene transcription, RNA metabolism and genome stability. The successful candidate(s) will be employed in the Svejstrup laboratory at the Department of Cellular and Molecular Medicine (ICMM) at the Faculty of Health and Medical Sciences, University of Copenhagen.

About the lab and the institute

In September 2020, the Svejstrup Laboratory will re-locate from the Francis Crick institute in London (http://www.crick.ac.uk/Jesper-svejstrup) to the ICMM.

Dr Svejstrup’s laboratory focuses on various aspects of transcription-associated genome instability and the cellular response to DNA damage obstructing transcription. Details of recent papers and research projects currently being undertaken can be found in the link above.

Research techniques used in the laboratory include: Cell biology, Biochemistry (including SILAC proteomics and reconstitution of key processes with purified factors in vitro) and modern Genome-wide techniques (ChIP-Seq, RNA-Seq, GRO-Seq, etc), as well as Genomic screening (siRNA and CRISPR screens).

Svejstrup lab represents cutting-edge interdisciplinary research and training. We will be located at ICMM in the new Mærsk Tower science building and at Panum. We will have access to state-of-the-art facilities for mass spectrometry, flow cytometry, cell engineering, and next-generation sequencing.

Project description

The positions are potentially related to several different projects: 1) Investigation aimed at gaining a deeper understanding of the molecular processes underlying transcription-coupled repair (TC-NER), with a particular focus on the transcription-repair coupling factors CSA and CSB, both encoded by genes that are mutated in the severe neurological disorder Cockayne syndrome. 2) A second area of interest is related to the process of transcript elongation, and in particular the mechanisms that allow RNA polymerase II to transcribe a gene with high fidelity and without loss of genome stability. 3) And a third new research area investigating transcription-related factors that govern nucleus-cytoplasm communication, and which ensure that the entire process of gene expression (from transcription in the nucleus to mRNA translation in the cytoplasm) is correctly regulated.

Principal supervisor is Jesper Svejstrup, ICMM, jsvejstrup@sund.ku.dk or jesper.svejstrup@crick.ac.uk

Start:             September 2020 or soon thereafter.

Duration:      3 years as a PhD student.

Job description

Your key tasks as a PhD student at SUND are:

  • Carry through an independent research project under supervisio
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Participate in active research environments including a stay at another research team
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Teach and disseminate your knowledge
  • Write a PhD thesis on the grounds of your project

Key criteria for the assessment of applicants

Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project

Other important criteria are:

  • The grade point average achieved
  • Professional qualifications relevant to the PhD project
  • Previous publications
  • Relevant work experience
  • Other professional activities
  • Curious mind-set with a strong interest in glycobiology
  • Excellent English skills written and spoken

Place of employment

The place of employment is at the Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen. ICMM offers a creative and ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programs, three high profile Research Centers as well as a number of international research groups. The scientists at ICMM are involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen. More information can be found at www.icmm.ku.dk

Terms of employment

The employment as PhD fellow is full time and for 3 years.

It is conditioned upon the applicant’s success­ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment

are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 27.593 DKK /approx. 3.697 EUR (April 2020-level) plus pension.

Questions

For specific information about the PhD fellowship, please contact the principal supervisor.

General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/

Application procedure

Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format: 

  1. Motivated letter of application (max. one page)
  2. CV incl. education, experience, language skills and other skills relevant for the position
  3. Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do
  4. Publication list (if possible)

Application deadline:  25 June 2020, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The Faculty of Health and Medical Sciences comprises approximately 7850 students, 1700 PhD students and 4800 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position. 

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Jesper Qualmann Svejstrup
E-mail: jsvejstrup@sund.ku.dk

Contact

Jesper Svejstrup
E-mail: jesper.svejstrup@crick.ac.uk

Info

Application deadline: 25-06-2020
Employment start: 01-09-2020
Working hours: Full time
Department/Location: Department of Cellular and Molecular Medicine


In your application, please refer to Professorpositions.com

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