PhD position available in endocrine regulation of metabolism and development

University of Copenhagen, Department Of Biology

Denmark

PhD position available in endocrine regulation of metabolism and development


Department Of Biology
Faculty of Science
University of Copenhagen

 

Department of Biology Faculty of Science at University of Copenhagen is offering a PhD scholarship in in endocrine regulation of metabolism and development commencing 01.01.2020 or as soon as possible thereafter.

 

Description of the scientific environment
The Rewitz lab is currently on the lookout for a number of Ph.D.-students .
The lab is working intensively on aspects of endocrine regulation of metabolism and development in the fruit fly Drosophila melanogaster, and the projects for which we are recruiting students are in this area.
The Rewitz lab at the moment comprises Kim Rewitz (Principal Investigator), two Assistant Professors, one Ph.D. student, six Master's students, and a laboratory manager/technician. Prior experience in Drosophila work or in the metabolism field is not necessary, but of course is a bonus.
No preference will be given in any way to any aspect of the applicant's non-scientific background, including ethnicity, sex and identity, nationality, and so on.

 

New facilities!
We have just completely rebuilt our fly facilities, so fly-pushers can work in a bright open space with plenty of storage space at the bench as well as in an 18-degree room. All-new fly scopes sit at every bench space. Incubators at a variety of temperatures are available.

 

In addition to this new space, the lab also has standard molecular-lab tools and apparatus – a qPCR machine and PCR machines; a plate reader for absorbance, fluorescence, DELFIA/TRFIA, and "Alpha" signals; and access to confocal microscopes (LSM 800 with AiryScan) as well as more-advanced imaging tools such as TEM, PALM/STORM, structured illumination microscopy, and so on.

 

Project one: cholesterol as a growth-regulating nutrient
Cholesterol is a famous molecule -- rightly so, and for many reasons. It is necessary as a structural component of cell membranes, providing fluidity (for example, this is one reason for which cold-water shrimp are high in cholesterol: it keeps their cell membranes from solidifying).
Cholesterol is also the chemical substrate for the synthesis of steroid hormones, both in mammals (for example, testosterone and estrogen) and in insects (the steroid hormone ecdysone). Dysfunction of biological cholesterol-management systems also leads to health defects, such as heart disease, stroke, and the Niemann-Pick class of cholesterol-storage diseases.
Furthermore, we recently found that dietary cholesterol regulates organismal and cellular growth in Drosophila larvae, with effects on nutrient signaling through the "master cellular regulator" Target of Rapamycin (Tor) as well as through the insulin-signaling system. In this work, we will investigate the precise ways that cholesterol affects metabolism and growth through genetic analyses and manipulations of the Tor and insulin pathways, through transcriptomic assessments, imaging, and other approaches. We will also probe the function of the Niemann-Pick-disease-related cholesterol-transport genes in various tissues, as well as the neuronal basis (if any) for cholesterol sensation and preference.

 

Project two: signals from the gut that regulate metabolism
Animal bodies are made up of a collection of different organs, each with different functions. To maintain energy homeostasis, each of them has access to different aspects of information about the internal nutritional state of the animal and of its environment. In our lab, one of our research goals is to identify hormonal signals that regulate metabolism; the gut, as the first organ that can assess recently eaten food, is a likely source of these signals. There are about two thousand potentially secreted proteins encoded in the fly genome, any of which might act as a hormonal signal from the gut to some other tissue – the brain, the fat, or the musculature – apprising them of new nutritional information. In this work, we aim to comprehensively screen the gut "secretome" for metabolism-regulating hormonal signals using a combination of unbiased transcriptomic correlations between tissues and tissue-specific gene knockdown and CRISPR manipulations. This project involves preparations for and analysis of transcriptomic data, RNAi screening, and metabolic assessment of animals, as well as follow-up studies on identified factors of interest through, e.g., genetic, metabolic, and imaging studies.


Principal supervisor is associate professor, Kim Rewitz, Department of Biology E-mail, kim.rewitz@bio.ku.dk.


Job description


The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:

 

To manage and carry through your research project
Attend PhD courses
Write scientific articles and your PhD thesis
Teach and disseminate your research
To stay at an external research institution for a few months, preferably abroad


Work for the department

Formal requirements
We are looking for a highly motivated and ambitious scientist with the following qualifications:

M.Sc. in Biology, Molecular biosciences, Genetics or other similar fields with good results
Experience with genetics and molecular cell biology
Experience with invertebrate model organisms
Ability to communicate in written and spoken English is required
Good communication and interpersonal skills
Well-organized, independent, driven and curious
As criteria for the assessment of your qualifications emphasis will also be laid on previous publications (if any) and relevant work experience.


Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.
Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.
The starting salary is currently at a minimum DKK 328.355 (approx. €43,750) including annual supplement (+ pension at a minimum DKK 53,360). Negotiation for salary supplement is possible.

 

Application Procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.

 

Please include

Cover Letter, stating which PhD project you are applying for and detailing your motivation and background for applying for the specific PhD project. -
CV
Diploma and transcripts of records (BSc and MSc)
Acceptance Letter for the relevant MSc Programme at SCIENCE, if any
Other information for consideration, e.g. list of publications (if any),
Full contact details (Name, address, telephone & email) of 1-3 professional referees



The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

 

Deadline for application
The dealine for applications is 01.11.2019, 23:59 GMT+1

 

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.
The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.



Questions
For specific information about the PhD scholarship, please contact the principal supervisor Associate Professor Kim Furbo Rewitz kim.rewitz@bio.ku.dk.



General information about PhD programmes at SCIENCE is available at http://www.science.ku.dk/phd.


In your application, please refer to Professorpositions.com

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