PhD Position in Biology

University of Bern

Switzerland

PhD Position in Biology

Welcome to the Zindel Lab at the University of Bern and Bern University Hospital, where we are pioneering the future of surgical regeneration under the leadership of Prof. Joel Zindel. Our dedicated team of scientists and clinicians is deeply committed to exploring the cellular and molecular immune-mechanisms of sterile injury repair in body cavities.

The Project:
We are excited to announce the opportunity to join our team for the SNSF-Starting-Grant-funded "MACScar – Macrophage Aggregation Control against Scarring" project. Your journey with us begins with a significant milestone - building upon our recent, groundbreaking research that was featured on the cover of Science. This is your chance to be part of a cutting-edge project, contributing to a significant leap in understanding the biology of body cavity macrophages and innate immunity to sterile injury.

The Position:
This is a fully SNSF-funded PhD student position (100%) starting in March 2023 (flexible upon mutual agreement). The candidate will have the opportunity to i) study the inter- and intracellular molecular mechanism of GATA6+ cavity macrophage activation, ii) investigate how these mechanisms affect healing and scarring by using pre-clinical injury models, and iii) perform and analyze next-generation screening experiments such as scRNA-Seq and spatial transcriptomics. As graduate student you will be enrolled in the GCB.
Requirements:
You should hold a master's degree. The willingness to conduct animal experiments is mandatory and previous hands-on experience working with mice (FELASA) is ideal. Flow cytometry, multiphoton microscopy, and data analysis (ImageJ/R) will have to be mastered for this project. A very high motivation and an analytical mind are required to tackle the complexity of the proposed project.
Who we are:
The Zindel lab is part of the Department of Visceral Surgery and Medicine at the University of Bern and the University Hospital of Bern. The PI, Joel Zindel, holds both a Cloëtta and SNSF Assistant Professor position. We are passionate about macrophages and microscopes. In fact, we are embedded in a world-class microscopy community (https://www.mic.unibe.ch) and we have our own cutting-edge multiphoton microscope (Leica Stellaris Dive) which we use to image the behavior of macrophages in their homeostatic niche in real-time. Check out the videos, they are worth a thousand words: https://www.science.org/doi/10.1126/science.abe0595. We rely on animal models, and we do so compassionately and in strict adherence to the 3R principles and legal regulations. Then, we validate our findings from pre-clinical models in the human system (primary human cells/tissues) which we harvest through several cohort studies directly from the operating room.
How to apply:
To discuss your career plans, please send your full application consisting of a motivation letter, your CV and the grades of your bachelor/master to Prof. Zindel at joel.zindel@unibe.ch.
We look forward to welcoming passionate individuals who are ready to make a meaningful impact!


In your application, please refer to Professorpositions.com

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