Starting date: From December 2023 onwards
The two PhD projects will aim to understand how mutations in specific epigenetic tumour suppressor genes control bladder cancer development and progression in cooperation with mutations in other oncogenic pathways. The projects will each use novel mouse models of bladder cancer, CRISPR-mediated genetic engineering, histology, multiplexed immunofluorescence microscopy, bladder organoid cultures, cell biological assays of cancer cell behaviour as well as state-of-the-art methods in molecular biology (RNA-seq, scRNA-seq, ATAC-seq, scATAC-seq, CUT&RUN and Exome-seq). It is planned that the two PhD students will work closely together on the mutually-complementary research projects and the diverse expertise available through the UcarE network will provide valuable opportunities for collaboration.