Post Doc in Pre-Clinical Cancer Drug Development

University of Copenhagen Department of Immunology and Microbiology

Denmark

Postdoc in Pre-Clinical Cancer Drug Development at Department of Immunology and Microbiology

We are looking for a highly motivated and dynamic researcher for a full time position to commence 1 February 2021 or as soon as possible.

Do you want to be part of a skilled research group developing first and best in class novel therapeutic drugs to combat cancer? Do you have experience with in vivo tumor models and immunotherapies? Then you might be the right candidate for this position!

Information on the department can be found at: https://isim.ku.dk/

Our research

Our research is focused on developing novel therapeutic and prophylactic protein based compounds to combat cancer as well as infectious diseases. In particular, we are working on utilizing a recombinant malaria protein (VAR2CSA) to target cancer. We have shown that this malaria protein binds to the vast majority of tumors and that it can be turned into a highly effective immunotherapy or drug conjugate. We work closely together with biopharmaceutical industry, CROs, CMOs and consultancies to ensure the success of our translational programs. You will be part of a team moving this novel cancer therapy through pre-clinical development to first in man studies. Based in Copenhagen, Denmark you will be working on these drug development programs in close collaboration with Canadian researchers and the UCPH spinout company VAR2Pharmaceuticals. We offer a position with great potential for personal development, acquisition of key competencies within pre-clinical drug development and importantly to participate in the development of first in class therapeutic compounds with a potential of making a huge impact on cancer.

We are a diverse group with many nationalities and our working environment is informal. We have regular group meetings where we discuss data, strategy and plan the work and you will be part of this and expected to contribute actively.

Your job

We have strong proof of concept that modalities of the recombinant malaria protein VAR2CSA can cure mice from tumours. Your job will be to take part in a team finalizing the pre-clinical development of a drug conjugate and an immunotherapy, with a primary focus on in vivo animal studies. This includes running cancer efficacy models, pharmacokinetic studies incl. bioassays and in vivo imaging studies using advanced IVIS Spectrum CT imaging system. In addition, some in vitro work on human cell cultures and flow cytometry is also expected. You will work closely together with a team of two technicians where you will be responsible for planning their work, writing and developing new protocols and supervise on a daily basis.

Profile

We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Essential experience and skills:

  • You have a PhD in pharmacology, biological sciences, or closely related disciplines
  • You are highly experienced in in vivo cancer models, primarily murine xenograft and/or orthotopic models
  • Preferable you have experience in cancer immunotherapy drug development
  • You have expert knowledge in cell cultures and experience with flow cytometry
  • You have experience with in vivo imaging using fluorescently labelled compounds
  • You have strong coordination skills and a structured approach to documentation and data management
  • You are able to work independently and manage and motivate a small team of technicians
  • You have an active interest in developing novel cancer compounds and bringing them towards the clinic
  • You have proficient communication skills and ability to work in teams
  • Excellent English skills written and spoken

Desirable experience and skills:

  • A strong background in both theoretical and practical cancer biology
  • Experience with pharmacokinetic studies and various immunoassays is desirable, but not necessary.

Place of employment

The place of employment is at Centre for Medical Parasitology at the Department of Immunology and Microbiology, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment.

You will join a team of dedicated researchers and technicians and will have access to modern laboratories, top quality animal facilities as well as state of the art imaging systems and flow cytometers. You will work in close collaboration with the private industry – while at the same time be part of an academic environment where truly explorative experimental work is being performed.

Terms of employment

The employment as postdoc is a full time and fixed-term position for 1 years with a great potential for being turned into a longer term position. Starting date is 1 February 2021 or after agreement.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 33,600 DKK/ approx. 4,480 Euro (April 2018-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Questions

If you are interested in hearing more about your possibilities and the position, do not hesitate to contact Professor Ali Salanti, +45 28757676

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure

Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).

2. CV incl. education, work/research experience, language skills and other skills relevant for the position.

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

4. List of publications.

Application deadline: 6th December 2020

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 51

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Ali Salanti
E-mail: salanti@sund.ku.dk

Info

Application deadline: 06-12-2020
Employment start: 01-02-2021
Working hours: Full time
Department/Location: Department of Immunology and Microbiology


In your application, please refer to Professorpositions.com

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