Postdoc in Cancer Genomics

University of Copenhagen

Denmark

Postdoc in cancer genomics in the Weischenfeldt group at BRIC

Faculty of Health and Medical Sciences, University of Copenhagen
 

We are looking for highly motivated, creative, and talented PhD-level computational biologist to join our team. The postdoc position is in computational biology and cancer genomics, with a focus on genomic structural variants and chromatin organisation in malignant hematopoiesis, commencing May 1st, 2020 or as soon as possible hereafter.


Our group and research

The Weischenfeldt lab is working on delineating the mutational mechanisms and clonal evolution of cancer, in particular mechanisms of structural variants and the impact on 3D chromatin organisation. We use orthogonal integrative approaches including WGS, single-cell, and long-read sequencing and chromatin conformation techniques in conjunction with development and application of computational approaches to understand how cancers mutate and evolve, which we are applying to cancer patient material in close collaboration with clinical colleagues at the hospital.


Project description

The project involves development of novel and executing existing computational methods to integrate patient-derived omics data with clinical information to i) identify novel driver alterations, in particular with respect to chromatin state and conformation and ii) pursue analysis of the clonal evolution of malignant hematopoiesis before and after therapy.

The successful candidate will be joining a larger team of cross-disciplinary cancer researchers, with the aims to identify new targets for therapy, optimize the use of already approved drugs, develop novel therapies, test potential novel drugs in pre-clinical models, and collaborate with pharmaceutical companies on developing new drugs and test these and other novel drugs in Phase I-II clinical trials.


Principal supervisor is group leader, Associate Professor Joachim Weischenfeldt, BRIC and Rigshospitalet, joachim.weischenfeldt@bric.ku.dk, Phone: +453545 604011


Your job
You will be working with data from patient-derived tumor material in collaboration with other team members. Your job will include oversight of the data quality and analyses using e.g. machine learning methods to integrate genomics, transcriptomics and epigenomics data set to identify mutational mechanisms and novel therapeutic targets in malignant hematopoiesis. A focus will be on integrating genomic aberrations with chromatin state and conformation to identify novel driver mechanisms in cancer. You will have the opportunity to develop your own research ideas and approaches. The position involves interdisciplinary research through exchange of ideas and results with clinicians and researchers involved in drug-testing in in vivo and in vitro models.


Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Essential experience and skills:

  • You have a PhD in computational biology or bioinformatics
  • You are highly experienced in working with NGS data and have worked with chromatin data
  • You have an active interest in cancer, mutational mechanisms and clonal evolution
  • Proficient communication skills and ability to work in teams
  • Excellent English skills written and spoken

Desirable experience and skills:

  • Experience with machine learning and statistics
  • Experience with chromatin conformation capture data
  • Knowledge on mutational mechanisms in cancer
  • Publications as co-author or first author in a related area
  • Fellowships, grants and prizes


Place of employment

The place of employment is at BRIC, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories and access to HPC.


Terms of employment
The employment as postdoc is full time for 2 years with possibility for prolongation. Starting date is May 1st, 2020 or after agreement.


Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,364 DKK/ approx. 4.598 Euro (Oktober 2019-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.


Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.


The position is covered by the “Ministerial Order on the Job Structure of Academic Staff at Universities of 11 December 2019.”


Questions
For further information please contact Joachim Weischenfeldt, joachim.weischenfeldt@bric.ku.dk; www.sund.ku.dk

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).


Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).

2. CV incl. education, work/research experience, language skills and other skills relevant for the position.

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

4. List of publications.


Application deadline: 12 February 2020, 23.59pm CET


We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.


The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.


You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.


Interviews are expected to be held in week 10 and 11.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.


APPLY NOW

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.


Info

Application deadline: 12-02-2020
Employment start: 01-05-2020
Working hours: Full time
Department/Location: BRIC


In your application, please refer to Professorpositions.com

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