Postdoctoral Fellow in Mitochondrial Biology

University of Cambridge

United Kingdom

The University of Cambridge wishes to appoint a postdoctoral scientist to join Dr Julien Prudent's Mitochondrial Physiology research group in the MRC Mitochondrial Biology Unit in Cambridge.

The postholder will work within a programme entitled "Molecular mechanisms regulating mitochondrial dynamics and mitochondria-organelle contact sites". Mitochondria are highly dynamic organelles constantly adapting their shape through fusion/fission events, to ensure their physiological functions. A critical discovery in the field of mitochondrial cell biology has been the identification of transient and specialized molecular structures connecting mitochondria with other organelles. These inter-organelle membrane contact sites are associated to signalling platforms, which allow metabolites and lipid exchanges require for mitochondrial functions.

The goal of the project is to finely decipher the molecular mechanisms regulating mitochondrial dynamics, the roles of organelle contact sites and the contribution of lipids, in particular phosphoinositides, in these complex shape transitions. Developing biochemical, cell biology and advanced microscopy methods, the post-holder will undertake research to study the interplay between mitochondrial ultrastructure, inner and outer membrane dynamics, mitochondria-organelle contact sites (ER, Golgi, lysosomes┬┐) and lipid fluxes. These mechanisms will then be studied in different physiological conditions including cell survival and death events, and inflammation.

Candidates will have (or be about to be awarded) a PhD in molecular and cellular biology, and a track record of related research achievements. Knowledge in mitochondrial cell biology including architecture and dynamics, but also other intracellular organelle dynamics (ER, lysosomes, Golgi) and/or membrane contact sites are essential. A strong experience in collection and processing of confocal and super-resolution microscopy data, including live cell imaging are also essential.

This is a fixed term training programme post for 3 years from date of appointment.

The MRC Mitochondrial Biology Unit is a world-renowned centre for research in respiratory enzymes. Additional information can be found at www.mrc-mbu.cam.ac.uk.

Applicants should include a CV and covering letter with their application, along with contact information for two professional referees who can be contacted prior to interview.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 15th March 2020

Interview date: TBC

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SM20631 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


In your application, please refer to Professorpositions.com

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