Postdoctoral Position at INEM in Circulating Rare Cells

Rarecells Diagnostics



The Institut Necker-Enfants Malades (INEM), created in January 2014, is an international biomedical research center located on the Necker Hospital campus, and supported by the French National Institute of Health and Medical Research (INSERM), the French National Center for Scientific Research (CNRS) and the University Paris Descartes.

The close interaction between the research labs and the clinical departments is one of our major strengths creating a highly dynamic environment and promoting translational and “bench to bedside” activities.

The INEM is the hub for cellular and molecular biology at University Paris Descartes, one of the World's leading universities. The Institute draws together over 100 talented scientists who are working together to translate research discoveries into applied more effective diagnostics and therapies.


Location: Paris

Full Time, 1 year renewable, with possible CDI position

Salary: According to experience


The post-holder will be based at INEM in the Circulating Rare Cells Research team within the “PRL/GH Pathophysiology: translational approaches" laboratory (Director: Dr Vincent Goffin) in the department of Cellular and Molecular Biology (INSERM Unit 1151). The Circulating Rare Cells Research team is working in a public/private partnership with the Company Rarecells Diagnostics. The post-holder will report directly to Professor Patrizia Paterlini-Bréchot, MD, PhD., inventor of the ISET® Technology for isolation and characterization of Circulating Tumor cells (CTC), internationally recognized by 80 independent scientific publications.


Project outline:

The collaborative project, funded within Transcan-JTC 2016 and entitled CLEARLY: Validation of multiparametric models and circulating and imaging biomarkers to improve lung cancer early detection aims to investigate mutations and transcript profiles of individual tumor cells circulating in blood of patients with lung cancer using advanced single cell-based molecular systems and advanced microscopy. The Researcher will also be involved in the development of single cell transcriptome analysis for the phenotypical study of circulating tumor cells contributing to unravel the mechanisms involved in tumor invasion.



INSERM U1151 is fully equipped to perform single cell genetic analysis on CTC isolated by ISET® with or without fixative. This includes in particular a laser microdissection system, equipment for single cell micromanipulation as well as a three step forward PCR lab space and equipment. The team has also access to the in house fully equipped Institut Imagine CGH and next generation sequencing platform (Life technology and Illumina instruments)



Candidates for the advertised position should be holders of PhD, or MD or both degrees with experience in Molecular Biology, Cellular biology or Genetics and Single cell molecular analyses. The successful candidate is expected to be highly motivated, to work independently, to have good communication skills and to be interested in technology development with clinical impact. Full proficiency in English language is required.


To apply please send a CV and a cover letter to:

In your application, please refer to


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