Postdoctoral Position in Cardiovascular Metabolism

University of Zurich

Switzerland


Institute, Department, Clinic

Institute of Clinical Chemistry of the University and University Hospital Zurich

Department Description

The group of cardio-metabolic research is part of the Institute of Clinical Chemistry of the University of Zurich and University Hospital Zurich. Our research combines basic and clinical research and investigates physio-pathological mechanisms leading to atherosclerosis in the context of metabolic derangements, like obesity and type 2 diabetes mellitus.

Responsibilities

The dysfunction of endothelial cells is a key player in cardiovascular and metabolic disease. However, the molecular mechanisms that disrupt endothelial homeostasis remain unclear. We examine the crosstalk between gut hormones, adipose tissue, and the cardiovascular system in health and disease. 

The postdoc’s focus will be on circulating bile acids (BA) and their role in metabolism in a variety of tissues and cells, including the endothelium. Open questions: how BA cooperate with lipoprotein to regulate endothelial metabolism and function. In turn, it is unknown whether endothelial cells influence local and systemic metabolic processes via the control of BA trafficking, and signaling. Samples collected from animal model or patients with obesity, type 2 diabetes and after bariatric surgery or other types of weight loss treatments will be analyzed in parallel.

This position requires a direct involvement in the experimental and clinical arms of the project and close interaction/supervision of PhD students.

Employment Level

100 %

Requirements / Qualifications

We are looking for a highly motivated candidate with a PhD, MD or MD/PhD degree with a strong background in cardiovascular and/or metabolic disease. Qualified applicants should have first-author research paper(s) published in peer-reviewed journals and have a strong interest in a multidisciplinary approach to experimental and clinical research. The ideal candidate shows initiative, is reliable and well organized, and shows social skills to work in an international team; first-hand experience with cardiovascular/metabolic animal models would be advantageous (e.g., metabolic phenotyping of rodent model of obesity, diabetes, genetically modified strains; surgical skills are a plus). The ability to design, evaluate and report research is required.

Language Skills

Excellent verbal and written communication skills in English. German is a plus.

Computer Skills

Office, GraphPad Prism 7,ImageJ and ImagePro. SPSS

Special Requirements

(Cardiovascular) laboratory techniques will include flow cytometry, single cell RNA sequencing, myograph vascular studies, advanced imaging techniques, i.e. echocardiography. Prior experience on primary endothelial and adipocytes research are a plus.

We offer

The project combines basic and clinical research. We work in close collaboration with the laboratory of Translational Nutrition Biology at ETH Zurich and the Veterinary Physiology at the University of Zurich.

For additional information about an employment at the University of Zurich please visit http://www.pa.uzh.ch/en/Willkommen-an-der-UZH.html

Starting Position

As early as possible. Upon agreement.

More information

More information is available here: https://www.cardiometabolicresearch.com/open-position , or you may contact Mrs. Elena Osto, M.D., Ph.D., FESC (email below)

Email

elena.osto@uzh.ch

Applications

Please send your complete application material, including cover letter, CV, statement of motivation, list of publications, and of 2 contacts for reference combined into one single PDF-file to elena.osto@uzh.ch

Elena Osto 
University of Zurich 
Institute of Clinical Chemistry 
-University of Zurich Wagistrasse 14 
8952 Schlieren-Zurich


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