Postdoctoral Research Associate in Pharmacology

University of Cambridge Department of Pharmacology

United Kingdom

Applications are invited for a Postdoctoral Research Associate position in the Marti-Solano group at the Department of Pharmacology, University of Cambridge (https://www.phar.cam.ac.uk/research/marti/research).

Our group leverages a range of state-of-the-art computational biology techniques to study G protein coupled receptors (GPCRs), an extensive family of proteins found across human cells and tissues. Individual family members detect different signals reaching the cell membrane and convey their messages to signalling partners that activate a variety of physiological responses inside our cells. Due to their capacity to regulate cell responses, GPCRs have become the most common drug targets. However, there are still many aspects of GPCR function that remain unresolved, thus hampering our understanding of the key molecular mechanisms that underlie receptor signalling in cell physiology and in therapeutic responses.

We are looking for a PDRA who can help us address some of these fundamental questions by analysing how differences in GPCR pathway composition can diversify receptor signalling responses across biological systems. This analysis can heavily impact the way in which we study GPCR physiology and drug action, as well as help explain the complex clinical responses of currently available GPCR drugs. The ideal candidate will have a PhD or equivalent qualification obtained in the last 3 years in bioinformatics or computational biology, with strong skills processing, analysing, visualising, and critically interpreting biological data. They should be proficient in at least one scripting language (R or Python) and have working experience with network biology reconstruction and analysis tools like Cytoscape and iGraph. They should be familiar with databases including the Gene Expression Atlas, the Human Protein Atlas, STRING, Reactome, or ChEMBL and have some background knowledge in multi-omics data analysis, cell signalling and / or molecular biology.

The successful candidate will be highly motivated, have excellent time management, organisational and communication skills, and have experience publishing their work. They should be able to work well as part of a team and in a multidisciplinary research environment. The role holder will be required to relocate to the Cambridge area and key responsibilities will include: establishing research objectives together with the principal investigator, leading their research project on a day-to-day basis, presenting their research in internal meetings and international conferences, taking an active part in manuscript writing, and translating new knowledge in the subject area into research activity. They will have the opportunity to supervise more junior group members and will be encouraged to contribute to teaching and dissemination activities.

Online interviews will take place in mid-February.

The expected starting date is May 2023, although there is some flexibility to start slightly earlier or later.

The Department holds an Athena SWAN bronze award and is committed to provide equal opportunities and advance the representation of women in science. We welcome applications from all candidates irrespective of gender. Appointment will be based on merit alone.

Fixed-term: The funds for this post are available for 36 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The application should include personal details, contacts for two referees, your CV, research publications list and cover letter. Informal enquiries about the position can be made to Dr Maria Marti-Solano (mm2402@cam.ac.uk).

For enquiries about the online application process please contact the HR Team, hr@phar.cam.ac.uk

Please quote reference PL34931 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


In your application, please refer to Professorpositions.com

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