Postdoctoral Scholar in Biomedical Science

University of California Berkeley

United States

Postdoctoral Scholar – Biomedical Science – Integrative Biology

Job #JPF03079
  • Integrative Biology / College of Letters & Science - Biological Sciences / UC Berkeley

Position overview

Position title:Postdoc
Salary range: Salary will be commensurate with qualifications and experience and based on UC Berkeley Postdoc series salary scale
Percent time: 100%
Anticipated start: Fall 2021
Position duration: One year with the possibility of extension based on performance and availability of funding.

Application Window

Open date: July 27th, 2021

Next review date: Tuesday, Aug 10, 2021 at 11:59pm (Pacific Time)
Apply by this date to ensure full consideration by the committee.

Final date: Wednesday, Sep 1, 2021 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.

Position description

The Department of Integrative Biology at the University of California, Berkeley seeks applications for a Postdoctoral scholar in the Brooks Lab, in the area of metabolic inflexibility in aging.

A postdoctoral position is immediately available in the Brooks and Vazquez-Medina Labs, Department of Integrative Biology, University of California, Berkeley. The successful applicant will join an NIH-funded interdisciplinary team studying the underlying causes of metabolic inflexibility in aging. While the work will focus on studies in cells and laboratory rodents, another arm of the effort involves parallel studies on young and old, physically fit and unfit men and women. Hence, the successful candidate will work with his/her counterpart on humans in vivo and analyze tissues isolated from them.

Research in the laboratory is focused on the effects of aging, exercise, and exercise training on mitochondrial biogenesis, energetics and dynamics in striated muscle (cardiac, red, white, intermediate), white adipose tissue (WAT), and brain. The tools of physiology, biochemistry and molecular biology are being applied to the discovery, and mitigation of factors that lead to mitochondrial fragmentation and loss of metabolic flexibility in aging. This work involves studies on cells and tissues isolated from young and old wild type and transgenic mice and rats.

Key responsibilities
Animal work
-Animal handling, care and husbandry (basic rodent procedures: intravenous, intraperitoneal and subcutaneous injection, gavage, anesthesia, genotyping).
-Exercise testing and training, euthanasia, tissue sampling, tissue fragmentation, organelle isolation.

Cell work
-Culture of established cell lines and primary cells (isolation, maintenance, genetic manipulation and analysis of cell phenotype).
-Mitochondrial function assessment in intact cells and isolated preparations using Oroboros and Seahorse systems.
-ROS detection using genetically encoded sensors and HPLC.

Analytical work
-Histochemical analyses of tissues and cells by confocal microscopy, RT-qPCR, Western blotting, ELISA, RNA-seq

  • Single Cell genomics (scRNAseq and multiomic profiling)
  • Epigenetic modification of histones via lactylation, methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation.

Other duties
-Support others conducting GC/MS and related technologies to determine metabolic flux rates and energy substrate partitioning in human subjects and lab animals.
-Equipment maintenance, ordering of supplies and maintenance of stock laboratory materials.
-Compliance with EH&S, ACUC and OLAC requirements.
-Data analysis and presentation at conferences, and publication in peer-reviewed journals.
-Training and mentoring undergraduate and graduate students in the laboratory.
-Assisting in the development of technical year-end reports.

University of California Postdoctoral Scholars are exclusively represented by the United Automobile, Aerospace and Agricultural Implement Workers of America (UAW). The union’s (UAW 5810) website is http://uaw5810.org/.

Details concerning available benefits as a Postdoctoral Scholar are set forth in Article 3, "Benefits," of the UC-UAW Local 5810 Collective Bargaining Agreement (CBA). A copy of the CBA between the University of California and the UAW is located at: http://ucnet.universityofcalifornia.edu/labor/bargaining-units/px/index.html.

The department is interested in candidates who will contribute to advancing diversity, equity, inclusion, and belonging.

Qualifications

Basic qualifications (required at time of application)

PhD (or equivalent international degree) or enrolled in a PhD (or equivalent international degree) program

Additional qualifications (required at time of start)

PhD (or equivalent international degree)
No more than four years of post-degree research experience by start date
Publication record

Preferred qualifications

PhD in physiology, biochemistry, biomedical science, or a related field.
Experience conducting independent research with in vivo and cellular models.
A solid, emerging record of research achievements.
Previous experience with exercise physiology or mitochondrial biology.

Application Requirements

Document requirements
  • Curriculum Vitae - Your most recently updated C.V.
  • Cover Letter
  • Statement of Research (Optional)
  • Statement on Contributions to Advancing Diversity, Equity, and Inclusion - Statement on your contributions to diversity, equity, and inclusion, including information about your understanding of these topics, your record of activities to date, and your specific plans and goals for advancing equity and inclusion if hired at Berkeley (for additional information go to https://ofew.berkeley.edu/recruitment/contributions-diversity).
  • (Optional)
Reference requirements
  • 3-5 required (contact information only)
Apply link: https://aprecruit.berkeley.edu/JPF03079

Help contact: gbrooks@berkeley.edu

Campus Information

Diversity, equity, inclusion, and belonging are core values at UC Berkeley. Our excellence can only be fully realized by faculty, students, and academic and non-academic staff who share our commitment to these values. Successful candidates for our academic positions will demonstrate evidence of a commitment to advancing equity, inclusion, and belonging.

The University of California, Berkeley is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct

In searches when letters of reference are required all letters will be treated as confidential per University of California policy and California state law. Please refer potential referees, including when letters are provided via a third party (i.e., dossier service or career center), to the UC Berkeley statement of confidentiality (http://apo.berkeley.edu/ucb-confidentiality-policy) prior to submitting their letter.

Job location

Berkeley, CA
 


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