Research Assistant / Associate in Toxicology

University of Cambridge

United Kingdom

Chimeric antigen receptor-T (CAR-T) cell therapy is an exciting new therapy that has dramatically altered the treatment of blood cancers, including leukaemia and lymphoma. It has also shown the potential to treat multiple myeloma, although it is not curative in that setting and all myeloma patients eventually relapse. To improve the outcomes, better CAR-T cell targets are needed.

We have developed methods to robustly interrogate the surface proteome of cancer cells and have recently quantified the entire surface proteome of primary myeloma, giving us a unique insight into potential novel CAR-T cell targets (manuscript under revision).

We are now looking to recruit a postdoctoral Research Associate to join our team in the research group of Dr Mike Chapman in the MRC Toxicology Unit, located within the University of Cambridge. The project will involve investigating candidate CAR-T cell targets, based on our existing data, developing novel CAR-T cells against the best of these, and performing preclinical testing of these in vitro and in vivo. The successful candidate will also have the opportunity to develop their own projects, in line with the interests of the laboratory.

The MRC Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including super resolution microscopy, advanced flow-cytometry, mass spectrometry and offers excellent opportunities for postdoctoral development. The Unit is currently located at Leicester and will physically relocate to the Gleeson Building, Cambridge in 2020. This post will initially be based within the Jeffrey Cheah Biomedical Centre on the Cambridge Biomedical Campus prior to relocation to the Gleeson Building.

Applicants must hold, or be close to completing, a PhD in a relevant discipline and have expertise in flow cytometry, tissue culture, and basic molecular biology (particularly cloning). Experience in protein purification, antibody production, and phage display screening would be an advantage, as would experience with bioinformatic approaches. The ability to work both independently and as part of a team, together with excellent communication and critical thinking skills are also essential.

Appointment at Research Associate is dependent on having a PhD. Where a PhD has yet to be awarded or submitted appointment will initially be made as a Research Assistant and amended to Research Associate when the PhD is awarded.

Fixed-term: The funds for this post are available for two years in the first instance.

Further information on the Toxicology Unit can be found at (https://www.mrc-tox.cam.ac.uk)

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are invited and can be directed to Mike Chapman (mac54@cam.ac.uk). If you have any queries regarding the application process please contact Rebecca Heatherley at rsh49@mrc-tox.cam.ac.uk

Please quote reference PU23578 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


In your application, please refer to Professorpositions.com

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