Research Assistant in Mechanistic Details of Protein Misfolding Diseases

University of Cambridge

United Kingdom

Fixed-term: The funds for this post are available for 1 year in the first instance.

Applications are invited for a Research Assistant role in the Centre for Misfolding Diseases to assist in studies related to understanding the mechanistic details involved in protein misfolding diseases. The project involves recombinantly expressing and purifying misfolding-related proteins and peptides, which will be used for a variety of biophysical analyses. The successful candidate will produce these proteins in bacteria and yeast expression systems, purify them using a variety of chromatography techniques (Akta purification systems, HPLC) and characterise their purity using optical spectroscopy, SDS-PAGE analysis and western blotting. Other duties may include, but are not limited to, site-directed mutagenesis, molecular cloning and assisting in running a busy laboratory (i.e. purchasing, maintenance of equipment related to protein purification, DNA/protein stock organisation).

The successful candidate will have a B.Sc degree (or equivalent) in a relevant biological science. They will be highly motivated and able to work independently. Excellent organisational and interpersonal skills are required to ensure success in liaising with a large and diverse team. Some experience with recombinant protein expression and purification is necessary, experience with standard molecular biology techniques is desirable but not essential.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

For queries regarding applying online for this post, please contact Karen Valelli (

For more information about the post please contact Prof. Michele Vendruscolo (

Please quote reference MA23422 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

In your application, please refer to


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