Research Assistant in Molecular Biology

Karolinska Institute Department of Oncology


Research Assistant in Molecular Biology


Do you want to contribute to improving human health?

The research team of Assistant Professor Sean Rudd is focused upon gaining a better understanding of chemotherapies currently employed in cancer treatment, and in particular how the metabolic processes within cancer cells can be exploited to enhance the efficacy of these therapies. Dr Rudd’s team is placed within the Helleday Laboratory, a multidisciplinary translational research group comprising of 30-40 scientists, which is located at the Stockholm node of Science For Life Laboratory, a national centre for molecular biosciences containing state-of-the-art high-throughput technology platforms.

Your mission

We are looking for a highly motivated and lab experienced Research Assistant to join Dr Rudd’s research team. Your main task will be to assist the on-going research projects in the group. This will entail using a variety of molecular/cell biology techniques in close collaboration with team members in order to deliver high-quality data in a timely manner.

In more detail, you will contribute to further understanding the role of the enzyme SAMHD1, a deoxynucleoside triphosphate triphosphohydrolase, in the metabolism of chemotherapies currently employed in cancer treatment. This work will follow on from our previous studies identifying SAMHD1 as a drug resistance factor in some haematological cancers (PMID: 28067901; PMID: 28401188) and our recent efforts to target this enzyme to overcome this barrier to treatment efficacy (PMID: 31950591).

Your profile

The following qualifications are required:

  • Proficiency in spoken and written English.
  • An MSc (or currently undertaking an MSc) in cell/molecular biology or equivalent discipline.
  • Documented lab experience. Being able to plan, perform and evaluate scientific research is required.
  • Good knowledge of Microsoft Office programs (Word, Excel, PowerPoint) and GraphPad Prism.
  • Cell lab experience in handling and culturing cancer cell lines is required, previous experience with cell lines derived from haematological malignancies is a merit.
  • Previously documented experience with techniques such as Western blot and cell death/viability assays is required. A strong merit would be previous experience with liquid handling equipment and microwell plate-based assays, in addition to multicolour flow cytometry, to assess cell death in cancer cell lines.
  • Previously documented experience working with antimetabolite chemotherapeutics and DNA precursor pool metabolic enzymes, such as SAMHD1, would be a strong merit

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Solna

The Helleday Laboratory

Science For Life Laboratory


Welcome to apply at the latest 2020-03-11.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employment Temporary position 3-6 months
Employment expires
Contract type Full time
First day of employment 2020-07-01 or according to agreement
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-1053/2020
Sean Rudd,
Union representative
Andreas Lundqvist, SACO, 08-517 768 84
Helen Eriksson, OFR, 08-524 823 38
Published 27.Feb.2020
Last application date 11.Mar.2020 11:59 PM CET


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