Research Associate in A New Role for Intermediate Filaments in the Secretory Pathway

University Of Manchester

United Kingdom

Research Associate - A New Role for Intermediate Filaments in the Secretory Pathway

Job Reference : BM&H-14494

Location : Oxford Road, Manchester

Closing Date (DD-MM-YYYY) : 30/09/2019

Salary : £32,816 to £33,797 per annum

Employment Type : Fixed Term

Faculty / Organisational Unit : Biology, Medicine & Health

Division : Molecular & Cellular Function

Hours Per week : Full time

Contract Duration : 1 November 2019 for 36 months

FBMH Introduction

The integrated structure of our Faculty enables a truly translational approach to biology, medicine and health - from pure discovery science through to clinical application and patient care. It also encourages collaborative working, enabling staff to deliver innovative, world-leading research that has a very real and positive impact on people’s lives, as well as high-quality education and training to over 11,000 undergraduate and postgraduate students.


A new role for intermediate filaments in the secretory pathway

The secretory pathway is required for the synthesis and modification of 30% of all cellular proteins and is essential for life. The Golgi apparatus lies at the heart of this pathway, and is responsible for the modification and sorting of secretory cargo proteins. Recently, we have obtained evidence suggesting a novel role for cytoplasmic intermediate filaments, a major cytoskeletal element, in Golgi organization and function.


We hypothesize that intermediate filaments contribute to both processes, and an interesting possibility is that they also contribute to mechanotransduction, physically coupling changes in cell mechanics to Golgi trafficking. The goal of this project is to investigate these possibilities to determine the function of intermediate filaments at the Golgi apparatus. Presently we have little knowledge of whether and how intermediate filaments associate with the secretory pathway, and this work aims to uncover a new role for this major class of cytoskeletal element in cell dynamics at the Golgi apparatus.


You will hold a PhD (or equivalent) in one of the biological sciences. Excellent communication skills and previous experience in biochemistry or cell biology is essential. Previous experience in studying membranes, protein trafficking, or the cytoskeleton, is highly desirable.
The post, which is funded by the BBSRC, is available for up to 3 years full-time from 1 November 2019. Joint supervision will be provided by Prof. Clair Baldock and Dr. Joe Swift, who are based within FBMH, and Dr. Thomas Waigh in the School of Physics and Astronomy.


As an equal opportunities employer we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit. The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. We particularly welcome applications from women for this post. All appointment will be made on merit. For further information, please visit:

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.

Enquiries about the vacancy, shortlisting and interviews:
Name: Prof Martin Lowe
Tel: 0161 850 2004


General enquiries:
Tel: 0161 275 4499


Technical support:
Tel: 0161 850 2004

This vacancy will close for applications at midnight on the closing date.

Please see link below for the Further Particulars document which contains the person specification criteria that you should address in your application.

In your application, please refer to


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