Research Associate in Biology

University of Cambridge

United Kingdom

The Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (

We are looking for a post-doctoral researcher to join the research team of Prof. Ludovic Vallier. The Vallier lab studies the mechanisms controlling human pluripotent stem cells (hPSCs) differentiation to generate cell types with a clinical interest for disease modelling and cell-based therapies. In particular, we are interested to study diseases mechanisms affecting the lungs. For that, we plan to perform single cell analyses on lung biopsies obtained from patients affected by a diversity of diseases including chronic disease and monogenetic disorders such as Cystic Fibrosis. Similar analyses will be performed on healthy tissues and on lung cells generated in vitro from human pluripotent stem cells (hPSCs). By comparing these different data set, we will reveal the cellular composition of the lungs in health and disease. We expect that specific cell types will play an essential role in disease category and that specific markers will help to identify these different populations. Such markers could represent new targets for therapeutic development. Thus, the function of key target genes will be validated using CRISPR/Cas9 genome editing in hPSCs. This project will be developed in close collaboration with pharmaceutical companies with the goal to deliver a research program with a strong translational focus.

The postholder will create state-of-the-art computational methods aiming to identify genes protective or inductive for lung diseases. For that, the postholder will use existing cutting edge software or devise new methods for analysing a variety of NGS datasets including single-cell and bulk RNAseq, ChIP-seq, and ATAC-Seq. He/she will interact regularly with the CSCI's Core Bioinformatics Group which regroups bioinformaticians dedicated to the application of modern bioinformatics techniques to stem cell research. Candidates should be familiar with a UNIX/Linux environment. Proficiency with an imperative programming/scripting language (e.g. Perl/Python/Java/C++) and statistical data analysis environments (R, Matlab) would be a strong advantage. Additional experience with analysis of Single Cell RNA-Seq and with the modelisation of regulatory networks is desirable. The post holder is also expected to support a diversity of projects within the Vallier group and to provide training for basic computational analyses.

Homepage: Requirements:

We are looking for candidates who hold a PhD, an equivalent research doctorate, or will obtain a PhD degree within six months in the field of single cell RNA-Seq computation analyses.

Skills and experience we are looking for include:

1) Research experience since completion of PhD. 2) Strong experience in Single Cell RNA-Seq. 3) Expertise in programming/scripting language (e.g. Perl/Python/Java/C++) and statistical data analysis environments (R, Matlab). 4) Previous experience with working in a close collaboration with wet lab scientists.

We are specifically looking for candidates that have effective communication skills and the ability to work in a team. The successful candidate is expected to take a lead role in the laboratory including training of research associate and students. Proven capacity to design, execute, and interpret your own experiments is essential.

Fixed-term: The funds for this post are available for 36 months in the first instance and will be subjected to renewal if fund become available.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date is 15th March 2020.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference PS22499 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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