Research Associate in Biomedical Sciences

University of Cambridge Biffi Laboratory

United Kingdom

The Biffi Laboratory at the CRUK Cambridge Institute (part of the University of Cambridge) is seeking to hire a bright and motivated Research Associate (post-doctoral level), with strong skills in molecular and cell biology to join a team working on studying and targeting the tumour microenvironment of pancreatic cancer.

The team combines ex vivo human and murine pancreatic tumour organoid/fibroblast co-cultures with murine in vivo models to study and target the interactions between pancreatic cancer cells and the surrounding microenvironment. Typical techniques used in the laboratory are flow cytometry, microscopy, single-cell RNA-sequencing, multiplexed immunohistochemistry, RNA in situ hybridization, drug and CRISPR/Cas9 strategies in both organoids and fibroblasts, and generation of transplantation models of pancreatic cancer.

The CRUK Cambridge Institute provides cutting-edge scientific infrastructure and expertise. The successful candidate will have access to our world class core facilities and laboratory resources.

The prospective candidate will be able to build on from a number of projects that have been already started, but is also encouraged to contribute with new, independent ideas. It is indeed expected that, as a post-doctoral member of the group, the successful candidate will have a significant input over the direction of its own project, will contribute with its original and innovative ideas, and will be willing to supervise more junior members of the laboratory.

The candidates should have (or be about to receive) a PhD in a relevant discipline. They should have a strong background in molecular biology and cell biology, with prior knowledge of tissue culture techniques, flow cytometry, microscopy and mouse work. Expertise in data analysis (e.g. analysis of bulk and single-cell RNA sequencing results), as well as chromatin immunoprecipitation is highly desirable.

Candidates are expected to be highly collaborative, good communicators, creative thinkers, able to find solutions to problems, to work effectively as part of a team and to contribute intellectually to other projects developed in the laboratory. For up to date information about the research group, please see our website at:

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 13th February 2020.

Interview date: TBC

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SW22128 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

In your application, please refer to


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