Research Associate in Genetics

University of Cambridge Department of Genetics

United Kingdom

An opportunity is available for a Postdoctoral Scientist to join the group of Dr. Michael Imbeault in the Department of Genetics, Cambridge - Our research is focused on characterizing the role of KRAB zinc finger proteins, the largest family of DNA binding factors in the human genome. While many of the projects in our lab relate to their function in transposable element regulation and the evolution of gene regulatory networks, this project is based on a new and exciting hypothesis related to genome stability.

There is emergent evidence that heterochromatin is a signal that is used locally to decide which pathway is used to repair DNA damage. The project is to probe this phenomenon at KRAB zinc finger targeted loci in the genome, as these proteins induce heterochromatin locally. The long-term aim is to understand the implications for human health - for example, if genomic stability is impacted in individuals with mutations in various KRAB zinc finger proteins or at specific binding sites they target. Through the project, the candidate will have the opportunity to develop a strong expertise in epigenetics and transposable elements.

The candidate is expected to undertake cutting edge research, acting as a lead on the project. The duties/responsibilities of this post include - working efficiently to reach objectives in a timely manner, keeping up to date with the latest literature, writing scientific reports on the research performed, collaborating with others on research projects in the lab, delivering research presentations and contributing to the smooth running of the Imbeault laboratory.

The successful candidate will be involved in the use and development of methods to quantify repair pathway choice and rare mutation profiles developing over time at precise genomic loci following genetic manipulations. The project requires a combination of various approaches, including the use of "traffic-light" reporter systems, deep sequencing, CRISPR/Cas9 and genetic KO mutants of KRAB zinc finger genes we have available in the lab. Although a plan has been designed to answer the question efficiently, the candidate will have the opportunity to provide their input and bring their own set of ideas and expertise.

We particularly welcome applications from women and candidates from a BME background for this vacancy as they are currently under-represented at this level in our University.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries about the role please contact Dr Michael Imbeault

Fixed-term: The funds for this post are available until October 2022 in the first instance.

Please quote reference PC23561 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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