Research Associate in Hematopoietic Stem Cell Biology

Imperial College London Department of Life Sciences

United Kingdom

Job summary

We are seeking to recruit an outstanding Research Associate, that is passionate about haematopoietic stem cells and their interactions with the bone marrow microenvironment. You will join the Haematopoietic Stem Cell Niche Laboratory, led by Dr Tiago C. Luis at the South Kensington Campus of Imperial College London. The Luis lab focuses on understanding the molecular mechanisms by which the bone marrow niche regulates haematopoietic stem cells...

Job listing information

  • Reference NAT00718
  • Date posted 7 July 2020
  • Closing date 6 August 2020

Key information about the role

  • Location South Kensington Campus (map)
  • Position type Full time, fixed term
  • Salary £40,215 – £47,579 plus benefits
  • Department Department of Life Sciences
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

We are seeking to recruit an outstanding Research Associate, that is passionate about haematopoietic stem cells and their interactions with the bone marrow microenvironment. You will join the Haematopoietic Stem Cell Niche Laboratory, led by Dr Tiago C. Luis at the South Kensington Campus of Imperial College London.

The Luis lab focuses on understanding the molecular mechanisms by which the bone marrow niche regulates haematopoietic stem cells (HSC) function in the maintenance of blood cells homeostasis and the development of haematological malignancies.

You will work on an exciting project aiming at understanding how myeloid leukaemia remodels the HSC niche to favour leukaemia development. This is a multidisciplinary project based on transgenic mouse models of leukaemia development, which will be analysed by multi-parameter flow cytometry, single-cell RNA sequencing, imaging and computational/systems biology methods. For more details on our research please see the laboratory web site.

Duties and responsibilities

You will drive the research project and will be responsible for independently running experiments and day-to-day project management and development. The project will involve a high degree of teamwork, interdisciplinary research and flexibility in developing and managing complex and demanding experimental protocols and data sets. 

Main duties:

  • To be pro-active in planning and conducting the research work and to perform data analysis, with appropriate supervision;
  • To ensure the validity and reliability of data at all times;
  • To perform research that fulfils the requirements of the grant objective;
  • To present findings to colleagues, collaborators and at conferences;
  • To draft publications and prepare them for submission to peer-reviewed journals;

Essential requirements

You must have a  PhD (or equivalent) in haematology, immunology, stem cell biology or related field;

You must be able to demonstrate

Experience with:

  • In vivo mouse models;
  • Flow Cytometry;
  • Gene expression analysis such as RT-qPCR and/or RNA sequencing;

Knowledge of:

  • Stem cell biology and/or haematopoiesis;
  • Research methods and data/statistical analysis in these fields;

Experience in Bioinformatics and imaging will be an asset. 

Further information

This is a full time, fixed term contract for 2 years.

Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £35,477 - £38,566 per annum.

For more information visit the laboratory web site. Should you require any further details on the role please contact Dr Tiago Luis (t.luis@imperial.ac.uk).

For technical issues when applying online please email recruitment@imperial.ac.uk

Committed to equality and valuing diversity, we are an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research


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