Research Associate in Immunology

University of Cambridge Cambridge Institute for Therapeutic Immunology and Infectious Disease

United Kingdom

Applications are invited from an enthusiastic and motivated post-doctoral scientist to join Professor Ken Smith's laboratory based in the Cambridge Institute for Therapeutic Immunology and Infectious Disease ( Work in the laboratory is focused on integrating high-throughput genomic and clinical data from patients with a range of immune-mediated diseases to gain insights into the underlying genetics and biological pathways that drives both disease susceptibility and prognosis, and how these may be targeted therapeutically to directly benefit patients. Recent publications from the laboratory include McKinney et al. Nature, 2015; Peters et al. PLoS Genetics, 2016, Lee et al. Nature Genetics, 2017; Biasci et al. Gut, 2019; Bashford-Rogers et al. Nature, 2019; Lyons et al. Nature Communications, 2019 and Thaventhiran et al. BioRxiv doi: 10.1101/499988.

This post will be focussed on applying novel integrative approaches to analyse cell type specific mRNA and miRNA transcriptomic data from 16 leukocyte subsets together with detailed multi-colour immunophenotyping data, antigen receptor repertoires, genetic and clinical meta-data to enable the building of predictive models of disease activity and outcome as well as the interpretation of data-derived factors associated with clinical parameters that provide insight into underlying biological processes.

The ideal candidate will have a PhD (or have recently submitted) in a relevant biological subject, together with proven expertise in molecular biology, cellular immunology and integrative analytical approaches. Experience with genome-wide association analyses, mRNA/miRNA transcriptomics, antigen receptor repertoire analyses and multi-parameter flow cytometry would be desirable. Excellent organisational skills and the ability to work as part of a team, as well as independently, are also essential.

Informal enquiries may be directed to Dr Paul Lyons (

Fixed-term: The funds for this post are available for 1 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 14th February 2020

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference RC22117 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

In your application, please refer to


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