Research Associate in Infectious Diseases

Imperial College London Department of Life Sciences

United Kingdom

Job summary

We are looking to appoint a Research Associate in infectious diseases to join the Department of Life Sciences at Imperial College London. You will be joining Professor Frankel’s Group based in the MRC Centre for Bacteriology Microbiology and Infection (CMBI), located in the Flowers Building, South Kensington Campus. The CMBI is a centre of excellence housing several groups studying bacterial pathogenesis, secretion systems, virulence and...

Job listing information

  • Reference NAT01061
  • Date posted 5 January 2022
  • Closing date 2 February 2022

Key information about the role

  • Location South Kensington Campus (map)
  • Position type Full time, fixed term
  • Salary £41,593 – £49,210 plus benefits
  • Department Department of Life Sciences
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

We are looking to appoint a Research Associate in infectious diseases to join the Department of Life Sciences at Imperial College London. You will be joining Professor Frankel’s Group based in the MRC Centre for Bacteriology Microbiology and Infection (CMBI), located in the Flowers Building, South Kensington Campus. The CMBI is a centre of excellence housing several groups studying bacterial pathogenesis, secretion systems, virulence and colonisation factors, gene expression, bacterial cell walls, toxins and biofilms.

Enteric bacterial infections and inflammation are intimately linked with metabolism and the microbiome. Recent studies illustrated the fluidity of the pathogenic state, which could be tilted towards commensalism by changes to diet and the composition of the microbiota. Moreover, we have shown that infections are orchestrated by intracellular type III secretion system effector networks (Cell Metabol. 26 (2017), 738-752.e6; Cell Reports 20 (2017), 2201-2214; Science 371 (2021); eabc9531; mBio. 26 (2021), e0241021; ).

You will use the natural mouse pathogen Citrobacter rodentium to model pathogen-host-microbiome interactions.

Candidates interested in infection, pathogenesis, inflammation and metabolism are encouraged to apply.

Duties and responsibilities

You will be expected to perform the outlined experiments to a high standard. In particular, you will be expected to:

  • Perform standard scientific techniques including cell culture, infection and in vivo mouse procedures
  • To perform detailed inflammatory profiling of infection
  • To conduct multiomic studies (g. metagenomics, transcriptomics and metabolomics) including large scale data analysis
  • To conduct bioinformatic analysis
  • To closely collaborate with specialists in ex vivo infection models (e.g. organoids)
  • To ensure the validity, reliability and reproducibility of data at all times
  • To present findings to colleagues and at conferences
  • To write up the findings for submission to refereed journals

Essential requirements

You must hold a PhD degree (or equivalent) in Molecular Cell Biology, Infection, Microbiome or related disciplines.

You must be able to demonstrate experience in the following areas:

  • Molecular biology and biochemistry
  • In vivo mouse work (a Home Office personal animal licence is desirable, but not essential)
  • Bioinformatics/data analysis

You must be able to demonstrate knowledge in the following areas:  

  • Cell biology of infection
  • Statistical and image analyses
  • Pathogen host interactions

It is essential that you have:  

  • The ability to work as part of a team and be open minded and cooperative
  • The ability to develop and apply new concepts and have a creative approach to problem solving
  • Excellent verbal and written communication skills
  • The ability to organise your own work with minimal supervision and prioritise in response to deadlines.

Further information

This is a full time, fixed-term position until 31 December 2023. You will be based at South Kensington Campus.

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.

Informal enquiries can be made directly to Professor Gad Frankel, Tel +44 20 7594 5253; email: g.frankel@imperial.ac.uk.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. /www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research


In your application, please refer to Professorpositions.com

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