Research Associate in Metabolic Science

University of Cambridge Institute of Metabolic Science

United Kingdom

A Postdoctoral Research Associate position is available within Dr Daniel Fazakerley's group at the Institute of Metabolic Science (IMS) at the University of Cambridge. Dr Fazakerley leads an innovative programme investigating mechanisms by which insulin signalling regulates glucose transport in adipose and muscle tissue, and how this process breaks down in metabolic disease. This position offers an ideal opportunity for a highly motivated scientist with a strong background in molecular and cell biology to work in a world-class research environment and to develop their career in cell biology, signalling and intra-cellular trafficking in the context of metabolic disease.

You will use state-of-the-art molecular and cell biology techniques to study glucose transporter trafficking and how this is regulated by insulin, and so define novel regulators of glucose transport in adipose and muscle tissue. Specifically, you will develop new glucose transporter reporter constructs, genetically manipulate (e.g. CRISPR-Cas9) disease relevant cell models, utilise super-resolution and high-throughput imaging techniques, and perform subcellular proteomics analyses. A good working knowledge of insulin signalling and/or protein trafficking processes would be highly advantageous.

To be considered for this position, you must possess a Ph.D. in a relevant field (i.e. cell biology, biochemistry) and have a solid understanding of, and experience with:

  • a broad range of molecular biology techniques, including recombinant DNA techniques and Western blotting
  • cell culture, including techniques for genome editing and/or siRNA and plasmid DNA delivery
  • live and fixed cell imaging techniques including confocal and total internal fluorescence microscopy, and image analysis.

Applicants should also be eligible for a Home Office Personal License.

Informal enquiries can be made to Dr Daniel Fazakerley, email:

Fixed-term: The funds for this post are available for 24 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Closing Date: 27th May 2021

Please quote reference RG26523 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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