Research Associate in Transcriptional Regulation in the Paediatric Cancer Neuroblastoma

University of Cambridge

United Kingdom

Neuroblastoma is a devastating paediatric cancer of the peripheral nervous system that causes 15% of all children's cancer deaths in the UK each year. Neuroblastoma arises from neuroblasts that fail to complete their normal developmental programme but are instead locked in a state of enhanced proliferation and inhibited differentiation. The goal of the Philpott lab is to exploit an understanding of normal neuroblast developmental control to restart differentiation in neuroblastoma cells by targeting a key transcriptional network both genetically and with drugs.

We are looking for a highly motivated post-doctoral scientist to join our collaborative research team to probe the molecular regulation of transcriptional networks that control proliferation versus differentiation of neuroblastoma cells. The successful candidate will use genome-wide techniques coupled with molecular analysis to interrogate the transcriptional and epigenetic control of gene pathways regulating proliferation versus differentiation in neuroblastoma cells, with the aim of developing new therapeutic approaches for this terrible disease.

The successful candidate will have a PhD or equivalent experience, considerable experience in stem cell biology, epigenetics, molecular biology, developmental biology or a similar field, and a proven track record in scientific publication. Prior experience in mammalian cell culture is essential. Experience of epigenetics and/or transcriptional regulation are essential, while experience of genome-wide transcriptional analysis and/or CRISPR methods would be an advantage. Applicants must display an ability to undertake project management, work within a multi-disciplinary team environment, have good presentation and communication skills and the ability to contribute to an environment supporting researchers at all stages of their careers.

Our group is housed in the Wellcome-MRC Cambridge Stem Cell Institute, a world-leading centre for stem cell research with the mission to transform human health through a deep understanding of stem cell biology. https://www.stemcells.cam.ac.uk/ .

Please contact Prof. Anna Philpott (ap113@cam.ac.uk) with any informal enquiries.

Fixed-term: The funds for this post are available for 36 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 11th April 2021.

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager

Please quote reference PS25984 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


In your application, please refer to Professorpositions.com

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