Researcher in Biochemistry

Syracuse University Chemistry

United States

Researcher in Biochemistry

Posting Details

Job # 076990
Job Title Postdoctoral Researcher - Biochemistry
Location Syracuse, NY
Pay Range $58,500
FLSA Status Exempt
As determined by principal investigator
Job Type Full-time
Rank Post Doc
Campus Syracuse, NY
Unionized Position Code Not Applicable
Job Description
The Castañeda lab uses a variety of biochemical and biophysical methods and techniques to uncover fundamental aspects of how proteins undergo liquid-liquid phase separation.We aim to determine how protein quality control mechanisms interface with membraneless organelle assembly and disassembly, particularly in how cells respond to stress.
We currently seek a researcher with background in biophysics and/or biochemistry to examine the physicochemical properties that determine physiological phase separation using molecular approaches such as NMR spectroscopy, small angle scattering, and single molecule FRET.
Our lab has multiple projects that focus on the role of liquid-liquid phase separation as it relates to the structure and function of ubiquitin-binding shuttle proteins.We are looking for driven and excited scientists to join our growing research group.The candidate will enter an openly collaborative environment with excellent colleagues/mentors and biophysical resources.
Our lab works with many other research labs at Syracuse University in the Departments of Biology and Chemistry as well as throughout the country, including the University of Michigan and St. Jude Children’s Research Hospital.The aims of the project are to examine how protein quality control components (including the proteasome, polyubiquitin chains, etc.) regulate the assembly and disassembly of biomolecular condensates, and to elucidate the underlying mechanisms of how domain-domain interactions alter and modulate phase separation.
The researcher will join an interdisciplinary environment with opportunities to learn new techniques and develop new research directions and ideas.Specific research goals will be discussed and agreed with the principal investigator.
  • Have a PhD or nearing completion of a PhD in biophysics or related area (e.g. biochemistry)
  • Possess skills in molecular cloning, protein expression, and protein purification.
  • Have excellent oral and written communication skills, pays attention to detail, is eager to present ideas and results at group meetings and conferences, and is highly organized with data management.
Job Specific Qualifications
  • Excited to lead new experiments to quantify phase transitions (e.g. UV/Vis spectrophotometric assays, light scattering, microscopy).
  • Willing to learn or have experience with biomolecular NMR spectroscopy of folded proteins or intrinsically disordered proteins.
  • Skilled or interested in using and developing other biophysical methods such as light scattering, small angle scattering, single molecule FRET.
    • Lead and be a team player in designing and executing biochemical and biophysical experiments, small angle scattering experiments, and other biophysical techniques to probe the structure, dynamics, and function of proteins involved in protein homeostasis and protein quality control pathways.
    • Clone, express and purify proteins from bacterial and other model systems
    • Develop and codify quantitative methods to analyze protein interactions and contributions to modulating phase separation and condensate formation/dissolution (including modeling, scripting in Python and R, Matlab, Mathematica, etc.)
    • Write detailed experimental protocols and keep meticulous lab notebooks
    • Communicate results clearly both in oral and written formats including talks, poster sessions, and journal articles.
    • Mentor graduate and undergraduate students, purchase supplies, maintain instrumentation, participate in literature discussions, and contribute to writing proposals.
    • Other duties as assigned.


Physical Requirements  
Application Instructions
In addition to completing an online application, please attach a curriculum vitae, cover letter, and a list of references.
About Syracuse University
Syracuse University is a private, international research university with distinctive academics, diversely unique offerings, and an undeniable spirit. Located in the geographic heart of New York State, with a global footprint, and over 150 years of history, Syracuse University offers a quintessential college experience.

The scope of Syracuse University is a testament to its strengths: a pioneering history dating back to 1870; a choice of more than 200 majors, 100 minors, and 200 advanced degree programs offered across the University’s 13 schools and colleges; over 15,000 undergraduates and over 6,000 graduate students; more than a quarter of a million alumni in 160 countries; and a student population from all 50 U.S. states and 123 countries. For more information, please visit
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Syracuse is a medium-sized city situated in the geographic center of New York State approximately 250 miles northwest of New York City. The metro-area population totals approximately 500,000. The area offers a low cost of living and provides many social, cultural, and recreational options, including parks, museums, festivals, professional regional theater, and premier shopping venues. Syracuse and Central New York present a wide range of seasonal recreation and attractions ranging from water skiing and snow skiing, hiking in the Adirondacks, touring the historic sites, visiting wineries along the Finger Lakes, and biking on trails along the Erie Canal.
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Syracuse University is an equal-opportunity, affirmative-action institution. The University prohibits discrimination and harassment based on race, color, creed, religion, sex, gender, national origin, citizenship, ethnicity, marital status, age, disability, sexual orientation, gender identity and gender expression, veteran status, or any other status protected by applicable law to the extent prohibited by law. This nondiscrimination policy covers admissions, employment, and access to and treatment in University programs, services, and activities.
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Quick Link
Job Posting Date 04/21/2023
Application Deadline  
Open Until Filled Yes
Priority Consideration  
Job Category Faculty
Message to Applicants  

Applicant Documents

Required Documents
  1. Resume/CV
  2. Cover Letter
  3. Reference List
Optional Documents

Supplemental Questions

Required fields are indicated with an asterisk (*).

  1. *How did you first find out about this position?
    • (Syracuse University Online Employment website)
    • Syracuse University HR Recruiter
    • Virtual Career Fair (via NYS Department of Labor)
    • SUNY EOC (Equal Opportunity Center)
    • Women’s Opportunity Center
    • Jubilee Homes
    • Syracuse Northeast Community Center
    • Interfaith Works
    • JobPlus
    • Chronicle of Higher Education
    • HERC (HERC Higher Ed Recruitment Consortium)
    • (Diverse Issues in Higher Education website)
    • LinkedIn Job Posting
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    • Search Firm
    • Referred by an SU Employee
    • Other
  2. If "other", please describe how you first found out about this position.

    (Open Ended Question)

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