Researchers in Translational Genomics of Diabetes

Uppsala University

Sweden

 

Uppsala University is a broad research university with a strong international standing. The task is to conduct research and education of the highest quality and to cooperate with society in various ways. Our most important asset is all the individuals who, with their curiosity and commitment, make Uppsala University one of the country's most exciting workplaces. Uppsala University has 44,000 students, 7,100 employees and a turnover of SEK 7 billion.

 

Department of Immunology, Genetics and Pathology at Uppsala University (www.igp.uu.se) has a broad research profile with strong research groups focused on cancer, autoimmune and genetic diseases. One of the basic ideas at the department is to stimulate translational research and thus closer collaboration between medical research and health care. Research is conducted in medical and clinical genetics, clinical immunology, pathology, neuronecology, vascular biology, radiation science and molecular tools. Parts of the business are also integrated with the departments of oncology, clinical genetics, clinical immunology, clinical pathology and hospital physics at Akademiska hospital. The department has teaching assignments in a number of program programs and master's programs in the medical faculty, as well as a number of programs in the field of technical and natural sciences. The department has a turnover of about SEK 400 million, of which just over half are external research grants. The number of employees is about 340, of which about 100 are doctoral students, and there are a total of over 600 employed in the workforce. 


Project Description:
Large-scale whole genome association studies (GWAS) have identified hundreds of genetic loci that are strongly associated with the risk of diabetes. In most cases, the causal genes, ie the genes behind the changes, are still uncharacterized. Before the results of GWAS can be translated into clinical use - for example, as new biomarkers or as drug targets - we must identify and characterize the causal genes in these loci. Recent developments in CRISPR-Cas9-based mutagenesis, high-throughput microscopy and image-based analysis have shown that zebrafish is a promising model system for systematic, large-scale, genetic characterization.
The overall goal of this project is to identify and characterize causal genes in GWAS-identified loci that are associated with the risk of diabetes using image-based zebrafish model systems.


Duties:
The service is funded by an international collaboration grant that aims to characterize diabetes candidate genes using human beta cells (Oxford), drosophila (Stanford) and zebrafish (Uppsala). The zebrafish part of the project includes: 1) creating CRISPR mutated fish using a multiplex strategy, ie where the effect of several genes can be studied simultaneously; 2) imaging diabetes-related features using an automated positioning system and fluorescence microscope; 3) preparing samples for further experimentation and sequencing; 4) objective quantification of image-based data; 5) quality control and analysis of sequencing results; 6) integration of multidisciplinary data and statistical analysis; 8) write reports and present the results to the consortium and at international meetings;


Qualification Requirements: The application is received by highly motivated candidates with a doctorate in molecular (cell) biology, molecular medicine, molecular epidemiology or the like. 
Written and oral proficiency in English is a prerequisite, as is documented and broad competence in basic molecular biology methodology and biostatistics. A successful applicant must be a motivated, organized and reliable team player who can also work independently. Previous knowledge and experience in fluorescence microscopy, epidemiology, programming or image-based analyzes are merit.


The Application should include a letter describing yourself, your research interests and experiences relevant to the service, a resume, a verified list of MSc course grades, a list of your publications in peer-reviewed journals, and contact information for at least two reference persons. If available, a thesis (completed or in preparation) and letters of recommendation can also be included.

Uppsala University values the qualities that equal gender distribution and diversity add to the business. We therefore like to see applicants of all genders and with different birth backgrounds, functionality and life experience.


Salary: Individual salary setting.


Access: Fastest.


Type of Employment: Time-limited employment of 2 years.


Scope of Employment: 100%


Information about the employment is provided by:
Marcel den Hoed: marcel.den_hoed@igp.uu.se, +46 (0) 70-425 0752


In your application, please refer to Professorpositions.com

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