Senior Scientific Associate

Europe's top cancer charity, Cancer Research UK, has combined with the University of Cambridge to fund the world class Cancer Research UK Cambridge Institute, situated on the Addenbrooke's Biomedical Campus in Cambridge.

As part of the University Of Cambridge School Of Clinical Medicine, the Institute's research ranges from basic cancer biology through translational cancer research to clinical application. The Institute currently houses over 400 researchers and support staff with 22 research groups. It provides a highly collaborative, multi-disciplinary environment in cancer research, with state of the art facilities and core scientific resources, and good links with the scientific community of Cambridge.

The Gilbertson group are currently looking for an Senior Scientific Associate to join their reseach group working on understanding the fundamental differences between paediatric and adult tumour initiation and progression with a focus on paediatric brain tumours. The position is funded by a Brain Tumour Charity grant. The project aims to test the hypothesis that epigenetic deregulation and remodelling of Group 3 Medulloblastoma drives resistance to conventional treatment. The successful candidate will work towards building a comprehensive map of Medulloblastoma epigenome evolution in response to conventional therapy. They will use an innovative recently developed pre-clinical trial platform(1), to provide access to tumour material as it progresses through different stages of treatment reponse and relapse, enabling direct study of epigenetic and transcriptional evolution in the context of medulloblastoma standard of care. The position will have close links to the Childrens Brain Tumour Centre of Excellence, and there will be opportunities to work closely with the centre.

The successful candidate will have a relevant masters degree or PhD with a record of significant research experience. Experience in cancer biology or a similar field is preferred. The candidate must have expertise in a variety of laboratory research techniques including; molecular biology, cell culture (ES and neurospheres), in vivo mouse experiments, tissue processing and immunohistochemical techniques. Experience of establishment and passaging patient tumour xenografts as well as pre-clinical drug testing would be an advantage. Applicants who wish to be considered for this position must display an ability to undertake project management, methods development, data collection and analysis and be able to work independently and interact well in a dynamic multi-disciplinary team environment.

(1) Nimmervoll BV, Boulos N, et al. (2018) Establishing a Preclinical Multidisciplinary Board for Brain Tumors Clin Cancer Res. Apr 1;24(7):1654-1666. doi: 10.1158/1078-0432.CCR-17-2168. Epub 2018 Jan 4.

For more information on the research project or the suitability of your research experience for the role, please email anna.nicholson@cruk.cam.ac.uk.

Fixed-term: The funds for this post are available until August 31st 2023 in the first instance..

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date is 19 May 2019, with the interview date TBC.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SW18881 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Further Information

• Senior Scientific Associate_Further Particulars

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